STRINGSTRING
Itgb2 Itgb2 Itgal Itgal Icam1 Icam1 Itgad Itgad Icam2 Icam2 Itgax Itgax Tln2 Tln2 Tln1 Tln1 Vcam1 Vcam1 Itga4 Itga4 Itga5 Itga5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Itgb2Integrin beta. (768 aa)    
Predicted Functional Partners:
Itgal
Integrin subunit alpha L; Belongs to the integrin alpha chain family.
   
 0.999
Icam1
Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). Belongs to the immunoglobulin superfamily. ICAM family.
   
 0.999
Itgad
Integrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity).
   
 0.999
Icam2
Intercellular adhesion molecule 2, isoform CRA_b.
   
 
 0.997
Itgax
Integrin subunit alpha X; Belongs to the integrin alpha chain family.
   
 0.997
Tln2
Talin 2.
   
 
 0.995
Tln1
RCG55135, isoform CRA_b.
   
 
 0.994
Vcam1
Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
   
 
 0.994
Itga4
Integrin subunit alpha 4; Belongs to the integrin alpha chain family.
   
 0.980
Itga5
Integrin alpha 5 (Mapped); Belongs to the integrin alpha chain family.
   
 0.978
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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