node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adprm | LOC314140 | ENSRNOP00000004560 | ENSRNOP00000069706 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | Ribose-phosphate pyrophosphokinase I -like. | 0.904 |
Adprm | Nudt5 | ENSRNOP00000004560 | ENSRNOP00000023893 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.905 |
Adprm | Nudt9 | ENSRNOP00000004560 | ENSRNOP00000002973 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate; Belongs to the Nudix hydrolase family. NudF subfamily. | 0.902 |
Adprm | Pgm1 | ENSRNOP00000004560 | ENSRNOP00000013785 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose. | 0.900 |
Adprm | Prps1 | ENSRNOP00000004560 | ENSRNOP00000071101 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.907 |
Adprm | Prps1l1 | ENSRNOP00000004560 | ENSRNOP00000066940 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | Phosphoribosyl pyrophosphate synthetase 1-like 1 (Predicted). | 0.904 |
Adprm | Prps2 | ENSRNOP00000004560 | ENSRNOP00000005615 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.904 |
LOC314140 | Adprm | ENSRNOP00000069706 | ENSRNOP00000004560 | Ribose-phosphate pyrophosphokinase I -like. | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. | 0.904 |
LOC314140 | Nudt5 | ENSRNOP00000069706 | ENSRNOP00000023893 | Ribose-phosphate pyrophosphokinase I -like. | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.906 |
LOC314140 | Nudt9 | ENSRNOP00000069706 | ENSRNOP00000002973 | Ribose-phosphate pyrophosphokinase I -like. | ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate; Belongs to the Nudix hydrolase family. NudF subfamily. | 0.905 |
LOC314140 | Pgm1 | ENSRNOP00000069706 | ENSRNOP00000013785 | Ribose-phosphate pyrophosphokinase I -like. | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose. | 0.919 |
LOC314140 | Prps1 | ENSRNOP00000069706 | ENSRNOP00000071101 | Ribose-phosphate pyrophosphokinase I -like. | Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.801 |
LOC314140 | Prps1l1 | ENSRNOP00000069706 | ENSRNOP00000066940 | Ribose-phosphate pyrophosphokinase I -like. | Phosphoribosyl pyrophosphate synthetase 1-like 1 (Predicted). | 0.801 |
LOC314140 | Prps2 | ENSRNOP00000069706 | ENSRNOP00000005615 | Ribose-phosphate pyrophosphokinase I -like. | Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. | 0.816 |
Nudt12 | Nudt14 | ENSRNOP00000061974 | ENSRNOP00000019550 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | Nudix (Nucleoside diphosphate linked moiety X)-type motif 14 (Predicted). | 0.841 |
Nudt12 | Nudt18 | ENSRNOP00000061974 | ENSRNOP00000015969 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | 8-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity). | 0.809 |
Nudt12 | Nudt5 | ENSRNOP00000061974 | ENSRNOP00000023893 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place w [...] | 0.867 |
Nudt12 | Nudt9 | ENSRNOP00000061974 | ENSRNOP00000002973 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate; Belongs to the Nudix hydrolase family. NudF subfamily. | 0.795 |
Nudt14 | Nudt12 | ENSRNOP00000019550 | ENSRNOP00000061974 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 14 (Predicted). | Nudix (Nucleoside diphosphate linked moiety X)-type motif 12 (Predicted). | 0.841 |
Nudt14 | Nudt18 | ENSRNOP00000019550 | ENSRNOP00000015969 | Nudix (Nucleoside diphosphate linked moiety X)-type motif 14 (Predicted). | 8-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity). | 0.870 |