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Jpt1 Jpt1 Mrps14 Mrps14 Klhl11 Klhl11 Rbm25l1 Rbm25l1 Get1 Get1 Ckap2l Ckap2l Fundc2 Fundc2 Gtse1 Gtse1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Jpt1Jupiter microtubule associated homolog 1, N-terminally processed; Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation. (149 aa)    
Predicted Functional Partners:
Mrps14
Mitochondrial ribosomal protein S14 (Predicted), isoform CRA_b.
   
  
 0.512
Klhl11
Kelch-like 11 (Drosophila) (Predicted).
      
 0.456
Rbm25l1
RNA-binding motif protein 25-like 1.
      
 0.453
Get1
Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane.
   
  
 0.439
Ckap2l
Cytoskeleton-associated protein 2-like.
      
 0.426
Fundc2
FUN14 domain-containing 2.
      
 0.414
Gtse1
Similar to B99 protein (Predicted).
   
  
 0.411
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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