STRINGSTRING
Ush2a Ush2a Whrn Whrn Pdzd7 Pdzd7 Ush1c Ush1c Adgrv1 Adgrv1 Vezt Vezt Ush1g Ush1g Cdh23 Cdh23 Clrn1 Clrn1 Pcdh15 Pcdh15 Myo7a Myo7a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Ush2aUsherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. (5162 aa)    
Predicted Functional Partners:
Whrn
Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
    
 0.993
Pdzd7
PDZ domain-containing 7.
    
 0.986
Ush1c
USH1 protein network component harmonin.
    
 0.970
Adgrv1
Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family.
     
0.969
Vezt
Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process.
    
 0.908
Ush1g
Usher syndrome 1G homolog (Human) (Predicted).
   
 
 0.852
Cdh23
Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
   
  
 0.847
Clrn1
Clarin-1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina; Belongs to the clarin family.
      
 0.842
Pcdh15
Protocadherin-related 15.
   
  
 0.841
Myo7a
Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 
 0.822
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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