STRINGSTRING
Alx1 Alx1 Pou1f1 Pou1f1 Pcdhgb6 Pcdhgb6 Lrriq1 Lrriq1 Inka1 Inka1 Zswim6 Zswim6 Nol11 Nol11 Npbwr1 Npbwr1 Tm6sf1 Tm6sf1 Leng1 Leng1 Six3 Six3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Alx1ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). Belongs to the paired homeobox family. (326 aa)    
Predicted Functional Partners:
Pou1f1
Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. Belongs to the POU transcription factor family. Class-1 subfamily.
   
 
 0.618
Pcdhgb6
Protocadherin gamma subfamily B, 6.
      
 0.567
Lrriq1
Leucine-rich repeats and IQ motif-containing 1.
 
  
 
 0.567
Inka1
Inka box actin regulator 1.
   
  
 0.507
Zswim6
Zinc finger, SWIM-type-containing 6.
    
 
 0.500
Nol11
Nucleolar protein 11.
   
  
 0.482
Npbwr1
Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals (By similarity); Belongs to the G-protein coupled receptor 1 family.
    
 
 0.452
Tm6sf1
Transmembrane 6 superfamily member 1 (Predicted), isoform CRA_b.
      
 0.439
Leng1
Leukocyte receptor cluster (LRC) member 1 (Predicted).
    
 
 0.436
Six3
SIX homeobox 3.
    
 
 0.428
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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