node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Birc2 | Birc3 | ENSRNOP00000014560 | ENSRNOP00000007702 | Baculoviral IAP repeat-containing 2. | Baculoviral IAP repeat-containing 3. | 0.983 |
Birc2 | Ikbkg | ENSRNOP00000014560 | ENSRNOP00000075158 | Baculoviral IAP repeat-containing 2. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.909 |
Birc2 | Map3k7 | ENSRNOP00000014560 | ENSRNOP00000007654 | Baculoviral IAP repeat-containing 2. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.993 |
Birc2 | Myd88 | ENSRNOP00000014560 | ENSRNOP00000018341 | Baculoviral IAP repeat-containing 2. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.908 |
Birc2 | Tab1 | ENSRNOP00000014560 | ENSRNOP00000075816 | Baculoviral IAP repeat-containing 2. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.872 |
Birc2 | Tab2 | ENSRNOP00000014560 | ENSRNOP00000021904 | Baculoviral IAP repeat-containing 2. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity). | 0.859 |
Birc2 | Tab3 | ENSRNOP00000014560 | ENSRNOP00000004854 | Baculoviral IAP repeat-containing 2. | TGF-beta-activated kinase 1 (MAP3K7)-binding protein 3. | 0.810 |
Birc2 | Traf6 | ENSRNOP00000014560 | ENSRNOP00000006148 | Baculoviral IAP repeat-containing 2. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.962 |
Birc2 | Ube2n | ENSRNOP00000014560 | ENSRNOP00000071283 | Baculoviral IAP repeat-containing 2. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.917 |
Birc3 | Birc2 | ENSRNOP00000007702 | ENSRNOP00000014560 | Baculoviral IAP repeat-containing 3. | Baculoviral IAP repeat-containing 2. | 0.983 |
Birc3 | Ikbkg | ENSRNOP00000007702 | ENSRNOP00000075158 | Baculoviral IAP repeat-containing 3. | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | 0.910 |
Birc3 | Map3k7 | ENSRNOP00000007702 | ENSRNOP00000007654 | Baculoviral IAP repeat-containing 3. | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] | 0.993 |
Birc3 | Myd88 | ENSRNOP00000007702 | ENSRNOP00000018341 | Baculoviral IAP repeat-containing 3. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.993 |
Birc3 | Tab1 | ENSRNOP00000007702 | ENSRNOP00000075816 | Baculoviral IAP repeat-containing 3. | TGF-beta-activated kinase 1/MAP3K7-binding protein 1. | 0.851 |
Birc3 | Tab2 | ENSRNOP00000007702 | ENSRNOP00000021904 | Baculoviral IAP repeat-containing 3. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity). | 0.859 |
Birc3 | Tab3 | ENSRNOP00000007702 | ENSRNOP00000004854 | Baculoviral IAP repeat-containing 3. | TGF-beta-activated kinase 1 (MAP3K7)-binding protein 3. | 0.810 |
Birc3 | Traf6 | ENSRNOP00000007702 | ENSRNOP00000006148 | Baculoviral IAP repeat-containing 3. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.932 |
Birc3 | Ube2n | ENSRNOP00000007702 | ENSRNOP00000071283 | Baculoviral IAP repeat-containing 3. | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] | 0.924 |
Ikbkg | Birc2 | ENSRNOP00000075158 | ENSRNOP00000014560 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | Baculoviral IAP repeat-containing 2. | 0.909 |
Ikbkg | Birc3 | ENSRNOP00000075158 | ENSRNOP00000007702 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral [...] | Baculoviral IAP repeat-containing 3. | 0.910 |