STRINGSTRING
Fem1b Fem1b Fnip1 Fnip1 Cul2 Cul2 Rbx1 Rbx1 Appbp2 Appbp2 Klhdc10 Klhdc10 Elob Elob Klhdc2 Klhdc2 Klhdc3 Klhdc3 Zyg11b Zyg11b Zer1 Zer1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Fem1bProtein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet (By similarity). Functions as an adapter/mediator in replication stress- induced signaling that leads to the activation of CHEK1 (By similarity); Belongs to the fem-1 family. (627 aa)    
Predicted Functional Partners:
Fnip1
UDENN FNIP1/2-type domain-containing protein.
   
 
 0.972
Cul2
Cullin 2; Belongs to the cullin family.
   
 0.932
Rbx1
Ring-box 1.
    
 0.827
Appbp2
Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity).
   
 0.797
Klhdc10
Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 (By similarity).
   
 0.773
Elob
Elongin-B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...]
    
 0.767
Klhdc2
Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.
   
 0.763
Klhdc3
Kelch domain-containing protein 3; May be involved in meiotic recombination process.
     
 0.763
Zyg11b
Zyg-11 family member B, cell cycle regulator.
   
 
 0.752
Zer1
Zyg-11-related, cell cycle regulator.
     
 0.748
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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