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Poglut3 Poglut3 Gxylt2 Gxylt2 Gxylt1 Gxylt1 Xxylt1 Xxylt1 Pofut1 Pofut1 Dnaaf5 Dnaaf5 Lrrc57 Lrrc57 Lrrc57-2 Lrrc57-2 Fam172a Fam172a Mrps25 Mrps25 Zbtb22 Zbtb22
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Poglut3Protein O-glucosyltransferase 3; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway. (508 aa)    
Predicted Functional Partners:
Gxylt2
Glucoside xylosyltransferase 2.
      
 0.678
Gxylt1
Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.
      
 0.658
Xxylt1
Xyloside xylosyltransferase 1.
      
 0.594
Pofut1
GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs) (By similarity). Plays a crucial role in NOTCH signaling. Initial fucosyl [...]
   
 
 0.584
Dnaaf5
Dynein, axonemal, assembly factor 5.
      
 0.535
Lrrc57
Leucine-rich repeat-containing protein 57.
   
  
 0.515
Lrrc57-2
Leucine-rich repeat-containing protein 57.
      
 0.510
Fam172a
Similar to Sperm 1 POU-domain transcription factor (SPRM-1) (Predicted).
   
  
 0.507
Mrps25
28S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family.
      
 0.506
Zbtb22
Zinc finger and BTB domain-containing 22.
   
  
 0.501
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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