STRINGSTRING
Rac2 Rac2 Ncf1 Ncf1 Cyba Cyba Cybb Cybb Ncf4 Ncf4 Vav1 Vav1 Dock2 Dock2 Pak1 Pak1 Plxnb1 Plxnb1 Tiam1 Tiam1 Prex1 Prex1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Rac2Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2). (192 aa)    
Predicted Functional Partners:
Ncf1
Neutrophil cytosolic factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
   
 0.999
Cyba
Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
   
 
 0.999
Cybb
Cytochrome b-245, beta polypeptide, isoform CRA_a.
   
 0.999
Ncf4
Similar to neutrophil cytosolic factor 4, isoform CRA_a.
   
 0.996
Vav1
Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
   
 0.989
Dock2
Uncharacterized protein; Belongs to the DOCK family.
   
 0.987
Pak1
Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...]
   
 0.978
Plxnb1
Plexin B1.
   
 0.975
Tiam1
TIAM Rac1-associated GEF 1.
    
 0.973
Prex1
Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1.
   
 0.972
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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