STRINGSTRING
Rsad2 Rsad2 Ifi44 Ifi44 Isg15 Isg15 Cmpk2 Cmpk2 Usp18 Usp18 Ifit1 Ifit1 Mx1 Mx1 Mx2 Mx2 Ifit3 Ifit3 Eif2ak2 Eif2ak2 Ifih1 Ifih1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Rsad2Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, thro [...] (362 aa)    
Predicted Functional Partners:
Ifi44
Interferon-induced protein 44, isoform CRA_a.
   
  
 0.970
Isg15
Interferon, alpha-inducible protein (Clone IFI-15K) (Predicted).
   
  
 0.968
Cmpk2
Cytidine/uridine monophosphate kinase 2.
   
  
 0.965
Usp18
Ubiquitin-specific peptidase 18; Belongs to the peptidase C19 family.
   
  
 0.956
Ifit1
Interferon-induced protein with tetratricopeptide repeats 1.
   
 
 0.951
Mx1
Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase which has antiviral activity against influenza A virus, (IAV) and Thogoto virus (THOV). Inhibits IAV by interefering with the process of primary transcription, probably by affecting the viral polymerase function (By similarity).
   
  
 0.942
Mx2
Interferon-induced GTP-binding protein Mx3; Does not show activity against influenza virus or VSV; although it only differs from Mx2 by 8 positions.
   
  
 0.928
Ifit3
Interferon-induced protein with tetratricopeptide repeats 3.
   
 
 0.927
Eif2ak2
Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...]
   
  
 0.927
Ifih1
Interferon-induced with helicase C domain 1.
   
  
 0.924
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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