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Osgep Osgep Tp53rk Tp53rk Gon7 Gon7 LOC685619 LOC685619 Tprkb Tprkb Tprkb-2 Tprkb-2 Yrdc Yrdc Lage3 Lage3 Moap1 Moap1 Ttc9c Ttc9c Ccnb1ip1 Ccnb1ip1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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OsgepProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa)    
Predicted Functional Partners:
Tp53rk
RCG32142, isoform CRA_b.
  
 0.985
Gon7
GON7 subunit of KEOPS complex.
    
 0.969
LOC685619
Similar to TP53-regulating kinase (p53-related protein kinase) (Nori-2).
  
 0.963
Tprkb
EKC/KEOPS complex subunit Tprkb; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification.
    
 0.960
Tprkb-2
EKC/KEOPS complex subunit Tprkb.
    
 0.960
Yrdc
YrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters.
  
 
 0.833
Lage3
Similar to Eso3 protein (Predicted).
   
 
 0.737
Moap1
Modulator of apoptosis 1.
     
  0.720
Ttc9c
Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family.
   
  
 0.672
Ccnb1ip1
Cyclin B1-interacting protein 1.
      
 0.627
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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