node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acy1 | Acy3 | ENSRNOP00000015852 | ENSRNOP00000024112 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity); Belongs to the AspA/AstE family. Aspartoacylase subfamily. | 0.796 |
Acy1 | Aldh18a1 | ENSRNOP00000015852 | ENSRNOP00000020940 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.714 |
Acy1 | Arg1 | ENSRNOP00000015852 | ENSRNOP00000017911 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.920 |
Acy1 | Arg2 | ENSRNOP00000015852 | ENSRNOP00000073568 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.921 |
Acy1 | Asl | ENSRNOP00000015852 | ENSRNOP00000001211 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.690 |
Acy1 | Aspa | ENSRNOP00000015852 | ENSRNOP00000072876 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). | 0.847 |
Acy1 | Ass1 | ENSRNOP00000015852 | ENSRNOP00000076301 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.835 |
Acy1 | Oat | ENSRNOP00000015852 | ENSRNOP00000022628 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Ornithine aminotransferase, mitochondrial. | 0.715 |
Acy1 | Otc | ENSRNOP00000015852 | ENSRNOP00000004686 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.968 |
Acy1 | Upb1 | ENSRNOP00000015852 | ENSRNOP00000055035 | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide; Belongs to the carbon-nitrogen hydrolase superfamily. BUP family. | 0.737 |
Acy3 | Acy1 | ENSRNOP00000024112 | ENSRNOP00000015852 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity); Belongs to the AspA/AstE family. Aspartoacylase subfamily. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.796 |
Acy3 | Aspa | ENSRNOP00000024112 | ENSRNOP00000072876 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids (By similarity); Belongs to the AspA/AstE family. Aspartoacylase subfamily. | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). | 0.613 |
Aldh18a1 | Acy1 | ENSRNOP00000020940 | ENSRNOP00000015852 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.714 |
Aldh18a1 | Arg1 | ENSRNOP00000020940 | ENSRNOP00000017911 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | 0.555 |
Aldh18a1 | Arg2 | ENSRNOP00000020940 | ENSRNOP00000073568 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.554 |
Aldh18a1 | Asl | ENSRNOP00000020940 | ENSRNOP00000001211 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. | 0.839 |
Aldh18a1 | Ass1 | ENSRNOP00000020940 | ENSRNOP00000076301 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure. Belongs to the argininosuccinate synthase family. Type 1 subfamily. | 0.866 |
Aldh18a1 | Oat | ENSRNOP00000020940 | ENSRNOP00000022628 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine aminotransferase, mitochondrial. | 0.999 |
Aldh18a1 | Otc | ENSRNOP00000020940 | ENSRNOP00000004686 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. | 0.697 |
Arg1 | Acy1 | ENSRNOP00000017911 | ENSRNOP00000015852 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. | Aminoacylase-1A; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). | 0.920 |