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Dupd1 Dupd1 Ppp1r7 Ppp1r7 Rpl5 Rpl5 Rbbp6 Rbbp6 Dysf Dysf Ms4a8 Ms4a8 LOC100911841 LOC100911841 Brms1 Brms1 Ampd1 Ampd1 Smim12 Smim12 Mthfsd Mthfsd
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Dupd1Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (215 aa)    
Predicted Functional Partners:
Ppp1r7
Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family.
    
 
 0.526
Rpl5
60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...]
   
 
 0.516
Rbbp6
Retinoblastoma binding protein 6, isoform CRA_a.
      
 0.475
Dysf
Dysferlin.
   
  
 0.466
Ms4a8
Membrane-spanning 4-domains, subfamily A, member 8B (Predicted).
      
 0.463
LOC100911841
Breast cancer metastasis-suppressor 1 homolog; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity).
      
 0.440
Brms1
Breast cancer metastasis-suppressor 1 homolog.
      
 0.440
Ampd1
AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism.
   
  
 0.432
Smim12
Small integral membrane protein 12.
   
 
 0.430
Mthfsd
Methenyltetrahydrofolate synthetase domain containing.
   
    0.414
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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