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Clec4f Clec4f Cd5l Cd5l Vsig4 Vsig4 D3ZXT7_RAT D3ZXT7_RAT Adgre1 Adgre1 Stab2 Stab2 Csf1r Csf1r Oit3 Oit3 Lyve1 Lyve1 Slc10a1 Slc10a1 Cd68 Cd68
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Clec4fC-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis. (550 aa)    
Predicted Functional Partners:
Cd5l
Cd5 molecule-like.
   
 
 0.787
Vsig4
V-set and immunoglobulin domain-containing 4.
   
  
 0.781
D3ZXT7_RAT
Ig-like domain-containing protein.
   
 
 0.608
Adgre1
Adhesion G protein-coupled receptor E2; Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.
   
 
 0.603
Stab2
175 kDa stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity o [...]
   
  
 0.578
Csf1r
Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...]
   
  
 0.572
Oit3
Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development.
   
 
 0.561
Lyve1
Extracellular link domain-containing 1 (Predicted).
   
 
 0.540
Slc10a1
Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
   
    0.536
Cd68
Cd68 molecule.
   
  
 0.518
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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