node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Afp | Epcam | ENSRNOP00000003879 | ENSRNOP00000021135 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family. | 0.669 |
Afp | Krt18 | ENSRNOP00000003879 | ENSRNOP00000067234 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Keratin, type I cytoskeletal 18; When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). Involved in the uptake of thrombin- antithrombin complexes by hepatic cells. | 0.731 |
Afp | Krt19 | ENSRNOP00000003879 | ENSRNOP00000019133 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). | 0.802 |
Afp | Krt7 | ENSRNOP00000003879 | ENSRNOP00000075566 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells; Belongs to the intermediate filament family. | 0.676 |
Afp | Krt8 | ENSRNOP00000003879 | ENSRNOP00000029068 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. | 0.606 |
Afp | Prom1 | ENSRNOP00000003879 | ENSRNOP00000069832 | Alpha-fetoprotein; Binds estrogens, fatty acids and metals; Belongs to the ALB/AFP/VDB family. | Prominin 1. | 0.576 |
Cav3 | Dag1 | ENSRNOP00000007601 | ENSRNOP00000026327 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | Dystroglycan 1. | 0.926 |
Cav3 | Dmd | ENSRNOP00000007601 | ENSRNOP00000029969 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | 0.967 |
Cav3 | Krt19 | ENSRNOP00000007601 | ENSRNOP00000019133 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). | 0.739 |
Cav3 | Krt8 | ENSRNOP00000007601 | ENSRNOP00000029068 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. | 0.729 |
Cav3 | Utrn | ENSRNOP00000007601 | ENSRNOP00000069754 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | Utrophin. | 0.854 |
Dag1 | Cav3 | ENSRNOP00000026327 | ENSRNOP00000007601 | Dystroglycan 1. | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | 0.926 |
Dag1 | Dmd | ENSRNOP00000026327 | ENSRNOP00000029969 | Dystroglycan 1. | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | 0.998 |
Dag1 | Krt19 | ENSRNOP00000026327 | ENSRNOP00000019133 | Dystroglycan 1. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). | 0.909 |
Dag1 | Krt8 | ENSRNOP00000026327 | ENSRNOP00000029068 | Dystroglycan 1. | Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. | 0.900 |
Dag1 | Utrn | ENSRNOP00000026327 | ENSRNOP00000069754 | Dystroglycan 1. | Utrophin. | 0.983 |
Dmd | Cav3 | ENSRNOP00000029969 | ENSRNOP00000007601 | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. | 0.967 |
Dmd | Dag1 | ENSRNOP00000029969 | ENSRNOP00000026327 | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | Dystroglycan 1. | 0.998 |
Dmd | Krt19 | ENSRNOP00000029969 | ENSRNOP00000019133 | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). | 0.935 |
Dmd | Krt8 | ENSRNOP00000029969 | ENSRNOP00000029068 | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. | Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. | 0.932 |