STRINGSTRING
Kazn Kazn Ppl Ppl Sh3rf3 Sh3rf3 Evpl Evpl Stambpl1 Stambpl1 Rims2 Rims2 LOC100910506 LOC100910506 Cask Cask St6galnac3 St6galnac3 Vrtn Vrtn Zdhhc14 Zdhhc14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
KaznKazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known (By similarity). (700 aa)    
Predicted Functional Partners:
Ppl
Periplakin (Predicted).
   
 0.972
Sh3rf3
SH3 domain-containing ring finger 3.
      
 0.614
Evpl
Envoplakin (Predicted).
   
 
 0.600
Stambpl1
STAM-binding protein-like 1.
      
 0.562
Rims2
Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity).
   
 
 0.542
LOC100910506
Uncharacterized protein.
    
 
 0.509
Cask
Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; Belongs to the MAGUK family.
    
 
 0.509
St6galnac3
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family.
   
  
 0.497
Vrtn
Vertebrae development-associated.
      
 0.487
Zdhhc14
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
   
  
 0.470
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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