node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aacs | Acaa1a | ENSRNOP00000001292 | ENSRNOP00000050691 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 0.658 |
Aacs | Bdh1 | ENSRNOP00000001292 | ENSRNOP00000002366 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | 0.935 |
Aacs | Bdh2 | ENSRNOP00000001292 | ENSRNOP00000019507 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.947 |
Aacs | Hmgcl | ENSRNOP00000001292 | ENSRNOP00000012853 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism; Belongs to the HMG-CoA lyase family. | 0.962 |
Aacs | Hmgcll1 | ENSRNOP00000001292 | ENSRNOP00000014927 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.944 |
Aacs | Hmgcs2 | ENSRNOP00000001292 | ENSRNOP00000026122 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.962 |
Aacs | Oxct1 | ENSRNOP00000001292 | ENSRNOP00000063646 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). | 0.965 |
Acaa1a | Aacs | ENSRNOP00000050691 | ENSRNOP00000001292 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.658 |
Acaa1a | Bdh1 | ENSRNOP00000050691 | ENSRNOP00000002366 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | 0.404 |
Acaa1a | Bdh2 | ENSRNOP00000050691 | ENSRNOP00000019507 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.773 |
Acaa1a | Hmgcl | ENSRNOP00000050691 | ENSRNOP00000012853 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism; Belongs to the HMG-CoA lyase family. | 0.703 |
Acaa1a | Hmgcll1 | ENSRNOP00000050691 | ENSRNOP00000014927 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.403 |
Acaa1a | Hmgcs2 | ENSRNOP00000050691 | ENSRNOP00000026122 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.928 |
Acaa1a | Oxct1 | ENSRNOP00000050691 | ENSRNOP00000063646 | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). | 0.681 |
Bdh1 | Aacs | ENSRNOP00000002366 | ENSRNOP00000001292 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.935 |
Bdh1 | Acaa1a | ENSRNOP00000002366 | ENSRNOP00000050691 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | 3-ketoacyl-CoA thiolase A, peroxisomal; Belongs to the thiolase-like superfamily. Thiolase family. | 0.404 |
Bdh1 | Bdh2 | ENSRNOP00000002366 | ENSRNOP00000019507 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (By similarity). | 0.970 |
Bdh1 | Hmgcl | ENSRNOP00000002366 | ENSRNOP00000012853 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism; Belongs to the HMG-CoA lyase family. | 0.981 |
Bdh1 | Hmgcll1 | ENSRNOP00000002366 | ENSRNOP00000014927 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. | 0.959 |
Bdh1 | Hmgcs2 | ENSRNOP00000002366 | ENSRNOP00000026122 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.758 |