node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Commd4 | Cul1 | ENSRNOP00000073885 | ENSRNOP00000007620 | COMM domain containing 4 (Predicted), isoform CRA_c. | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | 0.582 |
Commd4 | Fbxo30 | ENSRNOP00000073885 | ENSRNOP00000019918 | COMM domain containing 4 (Predicted), isoform CRA_c. | F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. | 0.514 |
Commd4 | Nedd8 | ENSRNOP00000073885 | ENSRNOP00000061284 | COMM domain containing 4 (Predicted), isoform CRA_c. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.603 |
Commd4 | Skp1 | ENSRNOP00000073885 | ENSRNOP00000073214 | COMM domain containing 4 (Predicted), isoform CRA_c. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.530 |
Commd4 | Uba3 | ENSRNOP00000073885 | ENSRNOP00000008893 | COMM domain containing 4 (Predicted), isoform CRA_c. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression. | 0.541 |
Commd4 | Ube2m | ENSRNOP00000073885 | ENSRNOP00000034271 | COMM domain containing 4 (Predicted), isoform CRA_c. | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. | 0.509 |
Cul1 | Commd4 | ENSRNOP00000007620 | ENSRNOP00000073885 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | COMM domain containing 4 (Predicted), isoform CRA_c. | 0.582 |
Cul1 | Fbxo30 | ENSRNOP00000007620 | ENSRNOP00000019918 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. | 0.612 |
Cul1 | Nedd8 | ENSRNOP00000007620 | ENSRNOP00000061284 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.998 |
Cul1 | Skp1 | ENSRNOP00000007620 | ENSRNOP00000073214 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.999 |
Cul1 | Uba3 | ENSRNOP00000007620 | ENSRNOP00000008893 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression. | 0.873 |
Cul1 | Ube2m | ENSRNOP00000007620 | ENSRNOP00000034271 | Cullin 1 (Predicted), isoform CRA_a; Belongs to the cullin family. | Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) (Predicted), isoform CRA_a; Belongs to the ubiquitin-conjugating enzyme family. | 0.973 |
D3ZGS7_RAT | Fau | ENSRNOP00000017230 | ENSRNOP00000028481 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Ubiquitin-like protein FUBI. | 0.932 |
D3ZGS7_RAT | Fbxo30 | ENSRNOP00000017230 | ENSRNOP00000019918 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. | 0.591 |
D3ZGS7_RAT | LOC687780 | ENSRNOP00000017230 | ENSRNOP00000034657 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | Ubiquitin-like protein fubi and ribosomal protein S30-like. | 0.860 |
D3ZGS7_RAT | LOC687780-2 | ENSRNOP00000017230 | ENSRNOP00000042031 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | FAU, ubiquitin like and ribosomal protein S30 fusion. | 0.860 |
D3ZGS7_RAT | Nedd8 | ENSRNOP00000017230 | ENSRNOP00000061284 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). | 0.467 |
D3ZGS7_RAT | Skp1 | ENSRNOP00000017230 | ENSRNOP00000073214 | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.570 |
Fau | D3ZGS7_RAT | ENSRNOP00000028481 | ENSRNOP00000017230 | Ubiquitin-like protein FUBI. | 40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. | 0.932 |
Fau | Fbxo30 | ENSRNOP00000028481 | ENSRNOP00000019918 | Ubiquitin-like protein FUBI. | F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. | 0.591 |