node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apaf1 | Bak1 | ENSRNOP00000010869 | ENSRNOP00000000576 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | BCL2-antagonist/killer 1, isoform CRA_b. | 0.773 |
Apaf1 | Bcl2l1 | ENSRNOP00000010869 | ENSRNOP00000069758 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. | 0.971 |
Apaf1 | Bcl2l11 | ENSRNOP00000010869 | ENSRNOP00000039006 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Bcl-2-like protein 11; Induces apoptosis and anoikis. | 0.794 |
Apaf1 | Bcl2l2 | ENSRNOP00000010869 | ENSRNOP00000020409 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | RCG23437, isoform CRA_b. | 0.793 |
Apaf1 | Becn1 | ENSRNOP00000010869 | ENSRNOP00000071966 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.465 |
Apaf1 | Bik | ENSRNOP00000010869 | ENSRNOP00000013977 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Bcl2-interacting killer, isoform CRA_a. | 0.506 |
Apaf1 | Bmf | ENSRNOP00000010869 | ENSRNOP00000010381 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Bcl-2-modifying factor; May play a role in apoptosis; Belongs to the Bcl-2 family. | 0.550 |
Apaf1 | Casp9 | ENSRNOP00000010869 | ENSRNOP00000017972 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | 0.999 |
Apaf1 | Pmaip1 | ENSRNOP00000010869 | ENSRNOP00000025361 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. | 0.724 |
Apaf1 | Tp53 | ENSRNOP00000010869 | ENSRNOP00000074031 | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.873 |
Bak1 | Apaf1 | ENSRNOP00000000576 | ENSRNOP00000010869 | BCL2-antagonist/killer 1, isoform CRA_b. | Apoptotic protease-activating factor 1; Regulates programmed cell death; necessary for normal brain development. Participates with pro-caspase-9 (Apaf-3) in the cytochrome c-dependent activation of caspase-3, leading to apoptosis. This activation requires ATP (By similarity). | 0.773 |
Bak1 | Bcl2l1 | ENSRNOP00000000576 | ENSRNOP00000069758 | BCL2-antagonist/killer 1, isoform CRA_b. | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis. | 0.994 |
Bak1 | Bcl2l11 | ENSRNOP00000000576 | ENSRNOP00000039006 | BCL2-antagonist/killer 1, isoform CRA_b. | Bcl-2-like protein 11; Induces apoptosis and anoikis. | 0.975 |
Bak1 | Bcl2l2 | ENSRNOP00000000576 | ENSRNOP00000020409 | BCL2-antagonist/killer 1, isoform CRA_b. | RCG23437, isoform CRA_b. | 0.939 |
Bak1 | Becn1 | ENSRNOP00000000576 | ENSRNOP00000071966 | BCL2-antagonist/killer 1, isoform CRA_b. | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] | 0.685 |
Bak1 | Bik | ENSRNOP00000000576 | ENSRNOP00000013977 | BCL2-antagonist/killer 1, isoform CRA_b. | Bcl2-interacting killer, isoform CRA_a. | 0.880 |
Bak1 | Bmf | ENSRNOP00000000576 | ENSRNOP00000010381 | BCL2-antagonist/killer 1, isoform CRA_b. | Bcl-2-modifying factor; May play a role in apoptosis; Belongs to the Bcl-2 family. | 0.689 |
Bak1 | Casp9 | ENSRNOP00000000576 | ENSRNOP00000017972 | BCL2-antagonist/killer 1, isoform CRA_b. | Caspase 9, isoform CRA_a; Belongs to the peptidase C14A family. | 0.726 |
Bak1 | Pmaip1 | ENSRNOP00000000576 | ENSRNOP00000025361 | BCL2-antagonist/killer 1, isoform CRA_b. | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family. | 0.912 |
Bak1 | Tp53 | ENSRNOP00000000576 | ENSRNOP00000074031 | BCL2-antagonist/killer 1, isoform CRA_b. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.981 |