STRINGSTRING
Npepo Npepo Agt Agt LOC360919 LOC360919 Cdh12 Cdh12 Suox Suox Ifi27l2b Ifi27l2b Cplx3 Cplx3 Syt6 Syt6 Crtac1 Crtac1 Cdkl1 Cdkl1 Papln Papln
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
NpepoAminopeptidase O; Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart. (822 aa)    
Predicted Functional Partners:
Agt
Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family.
     
 0.752
LOC360919
Similar to alpha-fetoprotein.
      
 0.745
Cdh12
Cadherin 12; Cadherins are calcium-dependent cell adhesion proteins.
      
 0.571
Suox
Sulfite oxidase, mitochondrial.
      
 0.537
Ifi27l2b
Interferon, alpha-inducible protein 27-like 2B.
   
  
 0.537
Cplx3
Similar to Complexin III (Predicted).
      
 0.510
Syt6
Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity); Belongs to the synaptotagmin family.
      
 0.499
Crtac1
Cartilage acidic protein 1.
      
 0.495
Cdkl1
Cyclin-dependent kinase-like 1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
      
 0.489
Papln
Papilin, proteoglycan-like sulfated glycoprotein.
      
 0.463
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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