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Ipcef1 Ipcef1 Cnksr3 Cnksr3 Cyth2 Cyth2 Cyth1 Cyth1 Cyth4 Cyth4 Cyth3 Cyth3 Mroh1 Mroh1 Nrip2 Nrip2 Tlcd4 Tlcd4 Sf3b5 Sf3b5 Extl1 Extl1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Ipcef1Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. (406 aa)    
Predicted Functional Partners:
Cnksr3
Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC); Belongs to the CNKSR family.
 
  
 
 0.930
Cyth2
Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity).
   
 
 0.736
Cyth1
Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity.
   
 
 0.732
Cyth4
Similar to cytohesin-4 (Predicted), isoform CRA_a.
   
 
 0.715
Cyth3
Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity).
   
 
 0.710
Mroh1
Maestro heat-like repeat family member 1.
      
 0.624
Nrip2
Nuclear receptor-interacting protein 2.
      
 0.593
Tlcd4
Transmembrane protein 56.
      
 0.589
Sf3b5
Splicing factor 3B subunit 5; Belongs to the SF3B5 family.
      
 0.496
Extl1
Exostoses (Multiple)-like 1 (Predicted); Belongs to the glycosyltransferase 47 family.
      
 0.494
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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