node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cnksr3 | Cyth2 | ENSRNOP00000024418 | ENSRNOP00000028588 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC); Belongs to the CNKSR family. | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | 0.614 |
Cnksr3 | Ipcef1 | ENSRNOP00000024418 | ENSRNOP00000024461 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC); Belongs to the CNKSR family. | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. | 0.930 |
Cyth1 | Cyth2 | ENSRNOP00000004196 | ENSRNOP00000028588 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | 0.666 |
Cyth1 | Cyth3 | ENSRNOP00000004196 | ENSRNOP00000001412 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | 0.635 |
Cyth1 | Cyth4 | ENSRNOP00000004196 | ENSRNOP00000071361 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Similar to cytohesin-4 (Predicted), isoform CRA_a. | 0.514 |
Cyth1 | Ipcef1 | ENSRNOP00000004196 | ENSRNOP00000024461 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. | 0.732 |
Cyth2 | Cnksr3 | ENSRNOP00000028588 | ENSRNOP00000024418 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC); Belongs to the CNKSR family. | 0.614 |
Cyth2 | Cyth1 | ENSRNOP00000028588 | ENSRNOP00000004196 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.666 |
Cyth2 | Cyth3 | ENSRNOP00000028588 | ENSRNOP00000001412 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | 0.607 |
Cyth2 | Cyth4 | ENSRNOP00000028588 | ENSRNOP00000071361 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | Similar to cytohesin-4 (Predicted), isoform CRA_a. | 0.514 |
Cyth2 | Ipcef1 | ENSRNOP00000028588 | ENSRNOP00000024461 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. | 0.736 |
Cyth3 | Cyth1 | ENSRNOP00000001412 | ENSRNOP00000004196 | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.635 |
Cyth3 | Cyth2 | ENSRNOP00000001412 | ENSRNOP00000028588 | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | 0.607 |
Cyth3 | Cyth4 | ENSRNOP00000001412 | ENSRNOP00000071361 | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Similar to cytohesin-4 (Predicted), isoform CRA_a. | 0.511 |
Cyth3 | Ipcef1 | ENSRNOP00000001412 | ENSRNOP00000024461 | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. | 0.710 |
Cyth4 | Cyth1 | ENSRNOP00000071361 | ENSRNOP00000004196 | Similar to cytohesin-4 (Predicted), isoform CRA_a. | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. | 0.514 |
Cyth4 | Cyth2 | ENSRNOP00000071361 | ENSRNOP00000028588 | Similar to cytohesin-4 (Predicted), isoform CRA_a. | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). | 0.514 |
Cyth4 | Cyth3 | ENSRNOP00000071361 | ENSRNOP00000001412 | Similar to cytohesin-4 (Predicted), isoform CRA_a. | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity). | 0.511 |
Cyth4 | Ipcef1 | ENSRNOP00000071361 | ENSRNOP00000024461 | Similar to cytohesin-4 (Predicted), isoform CRA_a. | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner. | 0.715 |
Cyth4 | Sf3b5 | ENSRNOP00000071361 | ENSRNOP00000019994 | Similar to cytohesin-4 (Predicted), isoform CRA_a. | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. | 0.536 |