node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bag1 | Dnajb1 | ENSRNOP00000011455 | ENSRNOP00000032313 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.855 |
Bag1 | Hsp90aa1 | ENSRNOP00000011455 | ENSRNOP00000075715 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock protein 90 alpha family class A member 1. | 0.777 |
Bag1 | Hspa1b | ENSRNOP00000011455 | ENSRNOP00000075599 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock protein family A (Hsp70) member 1B. | 0.992 |
Bag1 | Hspa4 | ENSRNOP00000011455 | ENSRNOP00000023628 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.997 |
Bag1 | Hspa8 | ENSRNOP00000011455 | ENSRNOP00000042159 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.989 |
Bag1 | LOC680121 | ENSRNOP00000011455 | ENSRNOP00000058593 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.994 |
Bag1 | St13 | ENSRNOP00000011455 | ENSRNOP00000025925 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Belongs to the FAM10 family. | 0.887 |
Dnajb1 | Bag1 | ENSRNOP00000032313 | ENSRNOP00000011455 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | 0.855 |
Dnajb1 | Hsp90aa1 | ENSRNOP00000032313 | ENSRNOP00000075715 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock protein 90 alpha family class A member 1. | 0.819 |
Dnajb1 | Hsp90ab1 | ENSRNOP00000032313 | ENSRNOP00000026920 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] | 0.884 |
Dnajb1 | Hspa1b | ENSRNOP00000032313 | ENSRNOP00000075599 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock protein family A (Hsp70) member 1B. | 0.955 |
Dnajb1 | Hspa4 | ENSRNOP00000032313 | ENSRNOP00000023628 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.979 |
Dnajb1 | Hspa8 | ENSRNOP00000032313 | ENSRNOP00000042159 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.979 |
Dnajb1 | LOC680121 | ENSRNOP00000032313 | ENSRNOP00000058593 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.984 |
Dnajb1 | Ptges3 | ENSRNOP00000032313 | ENSRNOP00000003787 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (By similarity). | 0.598 |
Dnajb1 | St13 | ENSRNOP00000032313 | ENSRNOP00000025925 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. Belongs to the FAM10 family. | 0.855 |
Hsp90aa1 | Bag1 | ENSRNOP00000075715 | ENSRNOP00000011455 | Heat shock protein 90 alpha family class A member 1. | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death f [...] | 0.777 |
Hsp90aa1 | Dnajb1 | ENSRNOP00000075715 | ENSRNOP00000032313 | Heat shock protein 90 alpha family class A member 1. | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.819 |
Hsp90aa1 | Hspa1b | ENSRNOP00000075715 | ENSRNOP00000075599 | Heat shock protein 90 alpha family class A member 1. | Heat shock protein family A (Hsp70) member 1B. | 0.999 |
Hsp90aa1 | Hspa4 | ENSRNOP00000075715 | ENSRNOP00000023628 | Heat shock protein 90 alpha family class A member 1. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.999 |