STRINGSTRING
Cd27 Cd27 Cd70 Cd70 Tnfsf4 Tnfsf4 Cd86 Cd86 Cd80 Cd80 Icoslg Icoslg Cd4 Cd4 Tnfrsf4 Tnfrsf4 Tnfrsf9 Tnfrsf9 Cd19 Cd19 Tnfrsf8 Tnfrsf8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cd27Similar to CD27 antigen-mouse, isoform CRA_b. (251 aa)    
Predicted Functional Partners:
Cd70
Cd70 molecule; Belongs to the tumor necrosis factor family.
    
 0.999
Tnfsf4
Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production (By similarity); Belongs to the tumor necrosis factor family.
      
 0.952
Cd86
Cd86 antigen, isoform CRA_c.
   
  
 0.940
Cd80
CD80 antigen, isoform CRA_a.
   
  
 0.938
Icoslg
Inducible T-cell co-stimulator ligand.
      
 0.914
Cd4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]
   
  
 0.904
Tnfrsf4
Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
   
  
 0.889
Tnfrsf9
Similar to T-cell antigen 4-1BB-mouse, isoform CRA_a.
      
 0.884
Cd19
CD19 molecule.
   
  
 0.880
Tnfrsf8
Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts (By similarity). Regulates gene expression through activation of NF-kappa-B.
   
  
 0.873
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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