node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dnajb1 | Dnajc3 | ENSRNOP00000032313 | ENSRNOP00000014182 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | 0.951 |
Dnajb1 | Hsf1 | ENSRNOP00000032313 | ENSRNOP00000047030 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock transcription factor 1. | 0.925 |
Dnajb1 | Hspa1a | ENSRNOP00000032313 | ENSRNOP00000067749 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.963 |
Dnajb1 | Hspa1b | ENSRNOP00000032313 | ENSRNOP00000075599 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock protein family A (Hsp70) member 1B. | 0.955 |
Dnajb1 | Hspa4 | ENSRNOP00000032313 | ENSRNOP00000023628 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.979 |
Dnajb1 | Hspa5 | ENSRNOP00000032313 | ENSRNOP00000025064 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.931 |
Dnajb1 | Hspa8 | ENSRNOP00000032313 | ENSRNOP00000042159 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.979 |
Dnajb1 | Hsph1 | ENSRNOP00000032313 | ENSRNOP00000001201 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.977 |
Dnajb1 | LOC680121 | ENSRNOP00000032313 | ENSRNOP00000058593 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.984 |
Dnajb1 | Stip1 | ENSRNOP00000032313 | ENSRNOP00000028743 | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1 (By similarity). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90. | 0.959 |
Dnajc3 | Dnajb1 | ENSRNOP00000014182 | ENSRNOP00000032313 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.951 |
Dnajc3 | Hspa1a | ENSRNOP00000014182 | ENSRNOP00000067749 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.506 |
Dnajc3 | Hspa1b | ENSRNOP00000014182 | ENSRNOP00000075599 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock protein family A (Hsp70) member 1B. | 0.632 |
Dnajc3 | Hspa4 | ENSRNOP00000014182 | ENSRNOP00000023628 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family. | 0.710 |
Dnajc3 | Hspa5 | ENSRNOP00000014182 | ENSRNOP00000025064 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] | 0.946 |
Dnajc3 | Hspa8 | ENSRNOP00000014182 | ENSRNOP00000042159 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. | 0.561 |
Dnajc3 | Hsph1 | ENSRNOP00000014182 | ENSRNOP00000001201 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.607 |
Dnajc3 | LOC680121 | ENSRNOP00000014182 | ENSRNOP00000058593 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity (By similarity). | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.553 |
Hsf1 | Dnajb1 | ENSRNOP00000047030 | ENSRNOP00000032313 | Heat shock transcription factor 1. | DnaJ (Hsp40) homolog, subfamily B, member 1 (Predicted), isoform CRA_a. | 0.925 |
Hsf1 | Hspa1a | ENSRNOP00000047030 | ENSRNOP00000067749 | Heat shock transcription factor 1. | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] | 0.898 |