node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bub1b | Cdca8 | ENSRNOP00000010406 | ENSRNOP00000043633 | BUB1 mitotic checkpoint serine/threonine kinase B. | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | 0.952 |
Bub1b | Espl1 | ENSRNOP00000010406 | ENSRNOP00000017314 | BUB1 mitotic checkpoint serine/threonine kinase B. | Extra spindle pole bodies-like 1, separase. | 0.981 |
Bub1b | Kif15 | ENSRNOP00000010406 | ENSRNOP00000071501 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. | 0.882 |
Bub1b | Kif18b | ENSRNOP00000010406 | ENSRNOP00000034491 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). | 0.859 |
Bub1b | Kif20a | ENSRNOP00000010406 | ENSRNOP00000037441 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.936 |
Bub1b | Kif2c | ENSRNOP00000010406 | ENSRNOP00000025903 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. | 0.953 |
Bub1b | Kif4a | ENSRNOP00000010406 | ENSRNOP00000073033 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.967 |
Bub1b | Kifc1 | ENSRNOP00000010406 | ENSRNOP00000061875 | BUB1 mitotic checkpoint serine/threonine kinase B. | Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. | 0.809 |
Bub1b | Pif1 | ENSRNOP00000010406 | ENSRNOP00000021265 | BUB1 mitotic checkpoint serine/threonine kinase B. | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] | 0.437 |
Bub1b | Troap | ENSRNOP00000010406 | ENSRNOP00000071862 | BUB1 mitotic checkpoint serine/threonine kinase B. | Trophinin-associated protein. | 0.769 |
Cdca8 | Bub1b | ENSRNOP00000043633 | ENSRNOP00000010406 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | BUB1 mitotic checkpoint serine/threonine kinase B. | 0.952 |
Cdca8 | Espl1 | ENSRNOP00000043633 | ENSRNOP00000017314 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Extra spindle pole bodies-like 1, separase. | 0.961 |
Cdca8 | Kif15 | ENSRNOP00000043633 | ENSRNOP00000071501 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly. | 0.876 |
Cdca8 | Kif18b | ENSRNOP00000043633 | ENSRNOP00000034491 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity). | 0.815 |
Cdca8 | Kif20a | ENSRNOP00000043633 | ENSRNOP00000037441 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.927 |
Cdca8 | Kif2c | ENSRNOP00000043633 | ENSRNOP00000025903 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome- microtubule attachment. | 0.947 |
Cdca8 | Kif4a | ENSRNOP00000043633 | ENSRNOP00000073033 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin family member 4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.905 |
Cdca8 | Kifc1 | ENSRNOP00000043633 | ENSRNOP00000061875 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. | 0.766 |
Cdca8 | Pif1 | ENSRNOP00000043633 | ENSRNOP00000021265 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] | 0.433 |
Cdca8 | Troap | ENSRNOP00000043633 | ENSRNOP00000071862 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA (By similarity). | Trophinin-associated protein. | 0.774 |