STRINGSTRING
Phactr1 Phactr1 Wdr37 Wdr37 Armc8 Armc8 Kcnj6 Kcnj6 Erich5 Erich5 Nxn Nxn Pde3a Pde3a Lrrc45 Lrrc45 Mrtfa Mrtfa Tspan2 Tspan2 Ano3 Ano3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
Phactr1Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity (By similarity). Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity). (415 aa)    
Predicted Functional Partners:
Wdr37
WD repeat domain 37 (Predicted), isoform CRA_a.
   
  
 0.732
Armc8
Armadillo repeat-containing 8.
      
 0.719
Kcnj6
G protein-activated inward rectifier potassium channel 2; This potassium channel is controlled by G proteins. It may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blocka [...]
   
  
 0.660
Erich5
Glutamate-rich 5.
      
 0.640
Nxn
Nucleoredoxin (Predicted), isoform CRA_a.
      
 0.619
Pde3a
cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
      
 0.604
Lrrc45
Leucine-rich repeat-containing 45.
      
 0.592
Mrtfa
Myocardin-related transcription factor A.
      
 0.541
Tspan2
Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
   
  
 0.524
Ano3
Anoctamin.
   
  
 0.510
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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