node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amfr | Aup1 | ENSRNOP00000072893 | ENSRNOP00000010602 | Autocrine motility factor receptor. | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | 0.653 |
Amfr | Derl1 | ENSRNOP00000072893 | ENSRNOP00000007484 | Autocrine motility factor receptor. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.976 |
Amfr | Derl2 | ENSRNOP00000072893 | ENSRNOP00000068885 | Autocrine motility factor receptor. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.868 |
Amfr | Derl3 | ENSRNOP00000072893 | ENSRNOP00000029737 | Autocrine motility factor receptor. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.733 |
Amfr | Fam8a1 | ENSRNOP00000072893 | ENSRNOP00000057242 | Autocrine motility factor receptor. | Family with sequence similarity 8, member A1. | 0.597 |
Amfr | LOC103694875 | ENSRNOP00000072893 | ENSRNOP00000074042 | Autocrine motility factor receptor. | Derlin-3. | 0.734 |
Amfr | Os9 | ENSRNOP00000072893 | ENSRNOP00000044914 | Autocrine motility factor receptor. | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). | 0.867 |
Amfr | Sel1l | ENSRNOP00000072893 | ENSRNOP00000043232 | Autocrine motility factor receptor. | Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (By similarity). May play a role in Notch signaling ; Belongs to the sel-1 family. | 0.951 |
Amfr | Syvn1 | ENSRNOP00000072893 | ENSRNOP00000028462 | Autocrine motility factor receptor. | Synovial apoptosis inhibitor 1, synoviolin, isoform CRA_b. | 0.832 |
Amfr | Vcp | ENSRNOP00000072893 | ENSRNOP00000040121 | Autocrine motility factor receptor. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.989 |
Aup1 | Amfr | ENSRNOP00000010602 | ENSRNOP00000072893 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Autocrine motility factor receptor. | 0.653 |
Aup1 | Derl1 | ENSRNOP00000010602 | ENSRNOP00000007484 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.656 |
Aup1 | Derl2 | ENSRNOP00000010602 | ENSRNOP00000068885 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.887 |
Aup1 | Derl3 | ENSRNOP00000010602 | ENSRNOP00000029737 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.689 |
Aup1 | Fam8a1 | ENSRNOP00000010602 | ENSRNOP00000057242 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Family with sequence similarity 8, member A1. | 0.681 |
Aup1 | LOC103694875 | ENSRNOP00000010602 | ENSRNOP00000074042 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Derlin-3. | 0.643 |
Aup1 | Os9 | ENSRNOP00000010602 | ENSRNOP00000044914 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity). | 0.598 |
Aup1 | Sel1l | ENSRNOP00000010602 | ENSRNOP00000043232 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (By similarity). May play a role in Notch signaling ; Belongs to the sel-1 family. | 0.925 |
Aup1 | Syvn1 | ENSRNOP00000010602 | ENSRNOP00000028462 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Synovial apoptosis inhibitor 1, synoviolin, isoform CRA_b. | 0.878 |
Aup1 | Vcp | ENSRNOP00000010602 | ENSRNOP00000040121 | Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.659 |