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Nap1l3 Nap1l3 Ube2o Ube2o Herc3 Herc3 Mcts1 Mcts1 Zfp367 Zfp367 H2az1 H2az1 M0R6X5_RAT M0R6X5_RAT H2az2 H2az2 Sdad1 Sdad1 Shisa4 Shisa4 Bex1 Bex1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Nap1l3Nucleosome assembly protein 1-like 3. (536 aa)    
Predicted Functional Partners:
Ube2o
Ubiquitin-conjugating enzyme E2O.
   
 
 0.607
Herc3
HECT and RLD domain-containing E3 ubiquitin protein ligase 3.
   
  
 0.591
Mcts1
Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Plays a role as translation enhancer; Recruits the density- regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; Up- regulates protein levels [...]
    
 
 0.571
Zfp367
Zinc finger protein 367; Transcriptional activator. May be involved in transcriptional activation of erythroid genes (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family.
   
 
 0.557
H2az1
Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...]
    
 
 0.555
M0R6X5_RAT
Histone H2A; Belongs to the histone H2A family.
    
 
 0.555
H2az2
Histone H2A; Belongs to the histone H2A family.
    
 
 0.555
Sdad1
Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.
    
 
 0.528
Shisa4
Transmembrane protein 58 (Predicted).
   
 
 0.524
Bex1
Protein BEX1; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states; Belongs to the BEX family.
   
  
 0.523
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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