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Ifna1 Ifna1 Ifnar1 Ifnar1 Ifnar2 Ifnar2 Irf3 Irf3 Irf7 Irf7 Nfkb1 Nfkb1 Rela Rela Ifngr1 Ifngr1 Ifnb1 Ifnb1 Jak2 Jak2 Egfr Egfr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
Ifna1Interferon alpha-1; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs to the alpha/beta interferon family. (192 aa)    
Predicted Functional Partners:
Ifnar1
Interferon (Alpha and beta) receptor 1 (Predicted), isoform CRA_a.
   
 0.969
Ifnar2
Interferon alpha and beta receptor subunit 2.
    
 0.947
Irf3
Interferon regulatory factor 3, isoform CRA_c.
     
 0.946
Irf7
Interferon regulatory factor 7.
     
 0.938
Nfkb1
Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]
     
 0.921
Rela
V-rel reticuloendotheliosis viral oncogene homolog A (Avian).
     
 0.909
Ifngr1
Interferon gamma receptor 1.
  
 
 0.784
Ifnb1
Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family.
  
 
0.748
Jak2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...]
     
 0.736
Egfr
Receptor protein-tyrosine kinase.
     
 0.735
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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