node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bcas1 | Cldn11 | ENSRNOP00000051984 | ENSRNOP00000014359 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | 0.502 |
Bcas1 | Enpp6 | ENSRNOP00000051984 | ENSRNOP00000013005 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | 0.708 |
Bcas1 | Ermn | ENSRNOP00000051984 | ENSRNOP00000029247 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). | 0.535 |
Bcas1 | Fancm | ENSRNOP00000051984 | ENSRNOP00000074177 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | FA complementation group M. | 0.726 |
Bcas1 | Gpr17 | ENSRNOP00000051984 | ENSRNOP00000032046 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. | 0.632 |
Bcas1 | Lims2 | ENSRNOP00000051984 | ENSRNOP00000075365 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. | 0.667 |
Bcas1 | Olig2 | ENSRNOP00000051984 | ENSRNOP00000000325 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Oligodendrocyte transcription factor 2. | 0.531 |
Bcas1 | Plp1 | ENSRNOP00000051984 | ENSRNOP00000003283 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. | 0.624 |
Bcas1 | Qk | ENSRNOP00000051984 | ENSRNOP00000070460 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). | 0.515 |
Bcas1 | Sox10 | ENSRNOP00000051984 | ENSRNOP00000015283 | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.499 |
Cldn11 | Bcas1 | ENSRNOP00000014359 | ENSRNOP00000051984 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | 0.502 |
Cldn11 | Ermn | ENSRNOP00000014359 | ENSRNOP00000029247 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). | 0.666 |
Cldn11 | Olig2 | ENSRNOP00000014359 | ENSRNOP00000000325 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Oligodendrocyte transcription factor 2. | 0.541 |
Cldn11 | Plp1 | ENSRNOP00000014359 | ENSRNOP00000003283 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. | 0.681 |
Cldn11 | Sox10 | ENSRNOP00000014359 | ENSRNOP00000015283 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.582 |
Enpp6 | Bcas1 | ENSRNOP00000013005 | ENSRNOP00000051984 | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | Breast carcinoma-amplified sequence 1 homolog; Required for myelination. | 0.708 |
Enpp6 | Gpr17 | ENSRNOP00000013005 | ENSRNOP00000032046 | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. | 0.525 |
Enpp6 | Olig2 | ENSRNOP00000013005 | ENSRNOP00000000325 | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | Oligodendrocyte transcription factor 2. | 0.546 |
Enpp6 | Plp1 | ENSRNOP00000013005 | ENSRNOP00000003283 | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. | 0.453 |
Enpp6 | Sox10 | ENSRNOP00000013005 | ENSRNOP00000015283 | Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids. Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.552 |