node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atxn3 | Hdac6-2 | ENSRNOP00000007505 | ENSRNOP00000063689 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Histone deacetylase 6. | 0.869 |
Atxn3 | Hsp90aa1 | ENSRNOP00000007505 | ENSRNOP00000075715 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Heat shock protein 90 alpha family class A member 1. | 0.503 |
Atxn3 | Runx2 | ENSRNOP00000007505 | ENSRNOP00000057733 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] | 0.531 |
Atxn3 | Vcp | ENSRNOP00000007505 | ENSRNOP00000040121 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] | 0.988 |
Cttn | Hdac6-2 | ENSRNOP00000050255 | ENSRNOP00000063689 | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-bas [...] | Histone deacetylase 6. | 0.944 |
Cttn | Hsp90aa1 | ENSRNOP00000050255 | ENSRNOP00000075715 | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-bas [...] | Heat shock protein 90 alpha family class A member 1. | 0.473 |
Cttn-2 | Hdac6-2 | ENSRNOP00000051742 | ENSRNOP00000063689 | Cortactin. | Histone deacetylase 6. | 0.876 |
Cttn-2 | Hsp90aa1 | ENSRNOP00000051742 | ENSRNOP00000075715 | Cortactin. | Heat shock protein 90 alpha family class A member 1. | 0.462 |
Hcls1 | Hdac6-2 | ENSRNOP00000003326 | ENSRNOP00000063689 | Hematopoietic cell-specific LYN substrate 1. | Histone deacetylase 6. | 0.933 |
Hcls1 | Hsp90aa1 | ENSRNOP00000003326 | ENSRNOP00000075715 | Hematopoietic cell-specific LYN substrate 1. | Heat shock protein 90 alpha family class A member 1. | 0.485 |
Hdac11 | Hdac6-2 | ENSRNOP00000008962 | ENSRNOP00000063689 | Histone deacetylase 11 (Predicted), isoform CRA_a. | Histone deacetylase 6. | 0.839 |
Hdac11 | Hsp90aa1 | ENSRNOP00000008962 | ENSRNOP00000075715 | Histone deacetylase 11 (Predicted), isoform CRA_a. | Heat shock protein 90 alpha family class A member 1. | 0.459 |
Hdac11 | Sirt2 | ENSRNOP00000008962 | ENSRNOP00000069934 | Histone deacetylase 11 (Predicted), isoform CRA_a. | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] | 0.690 |
Hdac6-2 | Atxn3 | ENSRNOP00000063689 | ENSRNOP00000007505 | Histone deacetylase 6. | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). In [...] | 0.869 |
Hdac6-2 | Cttn | ENSRNOP00000063689 | ENSRNOP00000050255 | Histone deacetylase 6. | Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity). Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover. In complex with ABL1 and MYLK regulates cortical actin-bas [...] | 0.944 |
Hdac6-2 | Cttn-2 | ENSRNOP00000063689 | ENSRNOP00000051742 | Histone deacetylase 6. | Cortactin. | 0.876 |
Hdac6-2 | Hcls1 | ENSRNOP00000063689 | ENSRNOP00000003326 | Histone deacetylase 6. | Hematopoietic cell-specific LYN substrate 1. | 0.933 |
Hdac6-2 | Hdac11 | ENSRNOP00000063689 | ENSRNOP00000008962 | Histone deacetylase 6. | Histone deacetylase 11 (Predicted), isoform CRA_a. | 0.839 |
Hdac6-2 | Hsp90aa1 | ENSRNOP00000063689 | ENSRNOP00000075715 | Histone deacetylase 6. | Heat shock protein 90 alpha family class A member 1. | 0.907 |
Hdac6-2 | Runx2 | ENSRNOP00000063689 | ENSRNOP00000057733 | Histone deacetylase 6. | Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] | 0.965 |