STRINGSTRING
Gkn2 Gkn2 Tff1 Tff1 Gkn1 Gkn1 Tff2 Tff2 Ankfn1 Ankfn1 Mucl3 Mucl3 RGD1565784 RGD1565784 Sfmbt2 Sfmbt2 Adam11 Adam11 A4gnt A4gnt Cldn18 Cldn18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gkn2Gastrokine-2. (184 aa)    
Predicted Functional Partners:
Tff1
Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
   
  
 0.810
Gkn1
Gastrokine 1.
  
  
0.689
Tff2
Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
   
  
 0.567
Ankfn1
Ankyrin-repeat and fibronectin type III domain containing 1.
      
 0.527
Mucl3
Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth.
   
  
 0.514
RGD1565784
RGD1565784 (Predicted).
      
 0.510
Sfmbt2
Scm-like with four mbt domains 2 (Predicted).
      
 0.468
Adam11
ADAM metallopeptidase domain 11.
   
  
 0.458
A4gnt
Alpha-1,4-N-acetylglucosaminyltransferase.
      
 0.442
Cldn18
Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.
   
  
 0.425
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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