node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Abl1 | Abl2 | ENSRNOP00000044534 | ENSRNOP00000056281 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.940 |
Abl1 | Raf1 | ENSRNOP00000044534 | ENSRNOP00000013831 | Tyrosine-protein kinase. | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] | 0.400 |
Abl1 | Rem1 | ENSRNOP00000044534 | ENSRNOP00000010149 | Tyrosine-protein kinase. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.521 |
Abl1 | Rin1-2 | ENSRNOP00000044534 | ENSRNOP00000066064 | Tyrosine-protein kinase. | Ras and Rab interactor 1. | 0.570 |
Abl2 | Abl1 | ENSRNOP00000056281 | ENSRNOP00000044534 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.940 |
Abl2 | Rin1-2 | ENSRNOP00000056281 | ENSRNOP00000066064 | Tyrosine-protein kinase. | Ras and Rab interactor 1. | 0.579 |
Als2 | Rab31 | ENSRNOP00000072428 | ENSRNOP00000063486 | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.500 |
Als2 | Rab5c | ENSRNOP00000072428 | ENSRNOP00000031520 | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.724 |
Als2 | Rabgef1 | ENSRNOP00000072428 | ENSRNOP00000001196 | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.792 |
Als2 | Rin1-2 | ENSRNOP00000072428 | ENSRNOP00000066064 | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | Ras and Rab interactor 1. | 0.641 |
Rab31 | Als2 | ENSRNOP00000063486 | ENSRNOP00000072428 | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | 0.500 |
Rab31 | Rabgef1 | ENSRNOP00000063486 | ENSRNOP00000001196 | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.849 |
Rab31 | Rin1-2 | ENSRNOP00000063486 | ENSRNOP00000066064 | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | Ras and Rab interactor 1. | 0.629 |
Rab5c | Als2 | ENSRNOP00000031520 | ENSRNOP00000072428 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | 0.724 |
Rab5c | Rabgef1 | ENSRNOP00000031520 | ENSRNOP00000001196 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | 0.914 |
Rab5c | Rin1-2 | ENSRNOP00000031520 | ENSRNOP00000066064 | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | Ras and Rab interactor 1. | 0.578 |
Rabgef1 | Als2 | ENSRNOP00000001196 | ENSRNOP00000072428 | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | Alsin; May act as a GTPase regulator (By similarity). Controls survival and growth of spinal motoneurons. | 0.792 |
Rabgef1 | Rab31 | ENSRNOP00000001196 | ENSRNOP00000063486 | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | 0.849 |
Rabgef1 | Rab5c | ENSRNOP00000001196 | ENSRNOP00000031520 | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] | 0.914 |
Rabgef1 | Rem1 | ENSRNOP00000001196 | ENSRNOP00000010149 | RAB guanine nucleotide exchange factor (GEF) 1 (Predicted), isoform CRA_a. | GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. | 0.597 |