node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cda | Dctd | ENSRNOP00000021036 | ENSRNOP00000017670 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.696 |
Cda | Dtymk | ENSRNOP00000021036 | ENSRNOP00000025644 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Deoxythymidylate kinase (Predicted), isoform CRA_b. | 0.651 |
Cda | Tk1 | ENSRNOP00000021036 | ENSRNOP00000067459 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. | 0.976 |
Cda | Tk2 | ENSRNOP00000021036 | ENSRNOP00000017269 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine kinase 2, mitochondrial (Predicted). | 0.954 |
Cda | Tymp | ENSRNOP00000021036 | ENSRNOP00000039935 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity); Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. | 0.991 |
Cda | Tyms | ENSRNOP00000021036 | ENSRNOP00000053086 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.813 |
Cda | Upp1 | ENSRNOP00000021036 | ENSRNOP00000006765 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.987 |
Cda | Upp2 | ENSRNOP00000021036 | ENSRNOP00000038248 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. | 0.987 |
Cmpk1 | Dctd | ENSRNOP00000068780 | ENSRNOP00000017670 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.929 |
Cmpk1 | Dtymk | ENSRNOP00000068780 | ENSRNOP00000025644 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxythymidylate kinase (Predicted), isoform CRA_b. | 0.798 |
Cmpk1 | Dut | ENSRNOP00000068780 | ENSRNOP00000009549 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. | 0.938 |
Cmpk1 | Tk1 | ENSRNOP00000068780 | ENSRNOP00000067459 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. | 0.930 |
Cmpk1 | Tk2 | ENSRNOP00000068780 | ENSRNOP00000017269 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidine kinase 2, mitochondrial (Predicted). | 0.929 |
Cmpk1 | Tyms | ENSRNOP00000068780 | ENSRNOP00000053086 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. | 0.546 |
Dctd | Cda | ENSRNOP00000017670 | ENSRNOP00000021036 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | 0.696 |
Dctd | Cmpk1 | ENSRNOP00000017670 | ENSRNOP00000068780 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. | 0.929 |
Dctd | Dtymk | ENSRNOP00000017670 | ENSRNOP00000025644 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxythymidylate kinase (Predicted), isoform CRA_b. | 0.966 |
Dctd | Dut | ENSRNOP00000017670 | ENSRNOP00000009549 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. | 0.962 |
Dctd | Tk1 | ENSRNOP00000017670 | ENSRNOP00000067459 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. | 0.980 |
Dctd | Tk2 | ENSRNOP00000017670 | ENSRNOP00000017269 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Thymidine kinase 2, mitochondrial (Predicted). | 0.966 |