Kl protein (Rattus norvegicus) - STRING network view

STRING 9.05

Kl protein (Rattus norvegicus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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	Kl	Klotho Precursor (EC 3.2.1.31) [Contains Klotho peptide]; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1014 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	Fgf23	Fibroblast growth factor 23 Precursor (FGF-23); Regulator of phosphate homeostasis (By similari [...] (251 aa)	•	•	0.971
	Ugt2b5	UDP-glucuronosyltransferase 2B5 Precursor (UDPGT 2B5)(EC 2.4.1.17)(17-beta-hydroxysteroid speci [...] (530 aa)	•		0.899
	Ugt2a1	UDP-glucuronosyltransferase 2A1 Precursor (UDPGT 2A1)(EC 2.4.1.17)(UGT-OLF); UDP-glucuronosyltr [...] (528 aa)	•		0.899
	Ugt2b	UDP-glucuronosyltransferase 2B2 Precursor (UDPGT 2B2)(EC 2.4.1.17)(3-hydroxyandrogen specific)( [...] (530 aa)	•		0.899
	Ugt1a1	UDP-glucuronosyltransferase 1-6 Precursor (UDPGT)(UGT1*6)(EC 2.4.1.17)(UGT1-06)(UGT1.6)(UGT1A6) [...] (535 aa)	•		0.899
	Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34 (532 aa)	•		0.899
	Ugt2b17	UDP-glucuronosyltransferase 2B1 Precursor (UDPGT 2B1)(UDPGTr-2)(EC 2.4.1.17); UDPGT is of major [...] (529 aa)	•		0.899
	Ugt2b36	UDP-glucuronosyltransferase 2B4 Precursor (UDPGT 2B4)(EC 2.4.1.17)(UDP-glucuronosyltransferase [...] (530 aa)	•		0.899
	Ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3 (534 aa)	•		0.899
	Gusb	Beta-glucuronidase Precursor (EC 3.2.1.31); Plays an important role in the degradation of derma [...] (808 aa)	•	•	0.876

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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