Msh2 protein (Rattus norvegicus) - STRING network view

STRING 9.05

Msh2 protein (Rattus norvegicus) - STRING network view

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	Msh2	DNA mismatch repair protein Msh2 (MutS protein homolog 2); Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers- MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, Mu [...] (933 aa)
		(Rattus norvegicus)
Predicted Functional Partners:
	Mlh1	DNA mismatch repair protein Mlh1 (MutL protein homolog 1); Heterodimerizes with Pms2 to form Mu [...] (758 aa)	•	•	•	•	•	•		0.998
	Msh6	mutS homolog 6 (E. coli) Gene (1361 aa)		•	•	•		•	•	0.973
	Pcna	Proliferating cell nuclear antigen (PCNA)(Cyclin); This protein is an auxiliary protein of DNA [...] (261 aa)			•	•		•		0.950
	Pms2	PMS2 postmeiotic segregation increased 2 (853 aa)	•	•	•	•		•		0.942
	Fen1	flap structure-specific endonuclease (380 aa)			•	•		•		0.923

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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