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hemA hemA hemL hemL hemC hemC hemB hemB gltX gltX HemD HemD hemN hemN cysG-1 cysG-1 cysG-2 cysG-2 lytB lytB hemE hemE
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query proteins and first shell of interactors
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second shell of interactors
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protein homology
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hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa)    
Predicted Functional Partners:
hemL
Glutamate-1-semialdehyde 2,1-aminomutase; Identified by similarity to EGAD:32046; match to protein family HMM PF00202; match to protein family HMM TIGR00713.
 
 0.997
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.983
hemB
Delta-aminolevulinic acid dehydratase; Identified by similarity to EGAD:38458; match to protein family HMM PF00490; Belongs to the ALAD family.
 
  
 0.956
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.929
HemD
Putative uroporphyrinogen-III synthase HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
  
 0.889
hemN
Oxygen-independent coproporphyrinogen III oxidase; Identified by similarity to SP:P77915; match to protein family HMM PF04055; match to protein family HMM PF06969; match to protein family HMM TIGR00538; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 0.767
cysG-1
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
 
  
 0.749
cysG-2
Siroheme synthase; Identified by similarity to EGAD:142433; match to protein family HMM PF00590; match to protein family HMM TIGR01469; match to protein family HMM TIGR01470.
 
  
 0.749
lytB
lytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
      
 0.683
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.603
Your Current Organism:
Neisseria meningitidis
NCBI taxonomy Id: 122586
Other names: N. meningitidis MC58, Neisseria meningitidis MC58, Neisseria meningitidis serogroup B strain MC58
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