node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apbA | dfp | Z0528 | Z5063 | Involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.514 |
apbA | panB | Z0528 | Z0145 | Involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.984 |
apbA | panC | Z0528 | Z0144 | Involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.980 |
apbA | panD | Z0528 | Z0142 | Involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.650 |
cmk | panC | Z1256 | Z0144 | Cytidylate kinase; Residues 1 to 227 of 227 are 100.00 pct identical to residues 1 to 227 of 227 from Escherichia coli K-12 Strain MG1655: B0910. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.908 |
coaA | dfp | Z5545 | Z5063 | Pantothenate kinase; Residues 1 to 308 of 308 are 100.00 pct identical to residues 9 to 316 of 316 from Escherichia coli K-12 Strain MG1655: B3974. | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.982 |
coaA | panC | Z5545 | Z0144 | Pantothenate kinase; Residues 1 to 308 of 308 are 100.00 pct identical to residues 9 to 316 of 316 from Escherichia coli K-12 Strain MG1655: B3974. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.957 |
dfp | apbA | Z5063 | Z0528 | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Involved in thiamin biosynthesis, alternative pyrimidine biosynthesis; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. | 0.514 |
dfp | coaA | Z5063 | Z5545 | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Residues 1 to 308 of 308 are 100.00 pct identical to residues 9 to 316 of 316 from Escherichia coli K-12 Strain MG1655: B3974. | 0.982 |
dfp | panB | Z5063 | Z0145 | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.712 |
dfp | panC | Z5063 | Z0144 | Flavoprotein affecting synthesis of DNA and pantothenate metabolism; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.913 |
gabT | gadA | Z3960 | Z4930 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.926 |
gabT | gadB | Z3960 | Z2215 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.951 |
gabT | goaG | Z3960 | Z2486 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.905 |
gabT | panC | Z3960 | Z0144 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.902 |
gabT | panD | Z3960 | Z0142 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.910 |
gadA | gabT | Z4930 | Z3960 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.926 |
gadA | gadB | Z4930 | Z2215 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.999 |
gadA | goaG | Z4930 | Z2486 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.925 |
gadA | panC | Z4930 | Z0144 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.932 |