node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gabT | gadA | Z3960 | Z4930 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.926 |
gabT | gadB | Z3960 | Z2215 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.951 |
gabT | goaG | Z3960 | Z2486 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.905 |
gabT | panC | Z3960 | Z0144 | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.902 |
gadA | gabT | Z4930 | Z3960 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.926 |
gadA | gadB | Z4930 | Z2215 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.999 |
gadA | gltB | Z4930 | Z4576 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212. | 0.952 |
gadA | goaG | Z4930 | Z2486 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.925 |
gadA | hdeA | Z4930 | Z4922 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Orf, hypothetical protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family. | 0.988 |
gadA | hdeD | Z4930 | Z4923 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Orf, hypothetical protein; Residues 1 to 190 of 190 are 100.00 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 Strain MG1655: B3511. | 0.990 |
gadA | panC | Z4930 | Z0144 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.932 |
gadA | xasA | Z4930 | Z2216 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Acid sensitivity protein, putative transporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfami [...] | 0.999 |
gadA | ybaS | Z4930 | Z0606 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Putative glutaminase; Residues 1 to 310 of 310 are 98.06 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 Strain MG1655: B0485; Belongs to the glutaminase family. | 0.983 |
gadA | yhiE | Z4930 | Z4925 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Orf, hypothetical protein; Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci (By similarity). Could be involved in the regulation of the genes coding for the type III secretion system in enterohaemorragic strains. | 0.982 |
gadB | gabT | Z2215 | Z3960 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.951 |
gadB | gadA | Z2215 | Z4930 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 0.999 |
gadB | gltB | Z2215 | Z4576 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212. | 0.952 |
gadB | goaG | Z2215 | Z2486 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | 4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.938 |
gadB | hdeA | Z2215 | Z4922 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Orf, hypothetical protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family. | 0.997 |
gadB | hdeD | Z2215 | Z4923 | Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). | Orf, hypothetical protein; Residues 1 to 190 of 190 are 100.00 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 Strain MG1655: B3511. | 0.968 |