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gadB gadB xasA xasA gadA gadA hdeA hdeA yhiE yhiE ybaS ybaS hdeD hdeD gltB gltB gabT gabT goaG goaG panC panC
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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gadBGlutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity). (466 aa)    
Predicted Functional Partners:
xasA
Acid sensitivity protein, putative transporter; Involved in glutamate-dependent acid resistance. Imports glutamate inside the cell while simultaneously exporting to the periplasm the GABA produced by GadA and GadB. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity); Belongs to the amino acid-polyamine-organocation (APC) superfami [...]
 
  
 0.999
gadA
Glutamate decarboxylase isozyme; Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria (By similarity).
  
0.999
hdeA
Orf, hypothetical protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family.
   
  
 0.997
yhiE
Orf, hypothetical protein; Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci (By similarity). Could be involved in the regulation of the genes coding for the type III secretion system in enterohaemorragic strains.
   
  
 0.980
ybaS
Putative glutaminase; Residues 1 to 310 of 310 are 98.06 pct identical to residues 1 to 310 of 310 from Escherichia coli K-12 Strain MG1655: B0485; Belongs to the glutaminase family.
  
 
 0.977
hdeD
Orf, hypothetical protein; Residues 1 to 190 of 190 are 100.00 pct identical to residues 1 to 190 of 190 from Escherichia coli K-12 Strain MG1655: B3511.
   
  
 0.968
gltB
Glutamate synthase, large subunit; Residues 1 to 1517 of 1517 are 99.53 pct identical to residues 1 to 1517 of 1517 from Escherichia coli K-12 Strain MG1655: B3212.
    
 0.952
gabT
4-aminobutyrate aminotransferase activity; Residues 1 to 426 of 426 are 98.59 pct identical to residues 1 to 426 of 426 from Escherichia coli K-12 Strain MG1655: B2662; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.951
goaG
4-aminobutyrate aminotransferase; Residues 1 to 421 of 421 are 98.57 pct identical to residues 1 to 421 of 421 from Escherichia coli K-12 Strain MG1655: B1302; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.938
panC
Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 
 0.932
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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