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glk glk ptsG ptsG zwf zwf pgi pgi crr crr eda eda pgm pgm tktA tktA malX malX galM galM yeaD yeaD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glkGlucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. (321 aa)    
Predicted Functional Partners:
ptsG
PTS system, glucose-specific IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration.
    
 0.968
zwf
Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.
 
 
 0.960
pgi
Glucosephosphate isomerase; Residues 1 to 549 of 549 are 100.00 pct identical to residues 1 to 549 of 549 from Escherichia coli K-12 Strain MG1655: B4025; Belongs to the GPI family.
    
 0.960
crr
PTS system, glucose-specific IIA component; Residues 1 to 169 of 169 are 99.40 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 Strain MG1655: B2417.
     
 0.944
eda
2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase; Residues 1 to 213 of 213 are 100.00 pct identical to residues 1 to 213 of 213 from Escherichia coli K-12 Strain MG1655: B1850.
 
 
 0.934
pgm
Phosphoglucomutase; Residues 1 to 546 of 546 are 99.63 pct identical to residues 1 to 546 of 546 from Escherichia coli K-12 Strain MG1655: B0688.
     
 0.927
tktA
Transketolase 1 isozyme; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
    
 0.923
malX
PTS system, maltose and glucose-specific II ABC; Residues 1 to 530 of 530 are 99.43 pct identical to residues 1 to 530 of 530 from Escherichia coli K-12 Strain MG1655: B1621.
    
 0.921
galM
Galactose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer.
  
  
 0.920
yeaD
Orf, hypothetical protein; Residues 1 to 301 of 301 are 97.00 pct identical to residues 1 to 301 of 301 from Escherichia coli K-12 Strain MG1655: B1780; Belongs to the glucose-6-phosphate 1-epimerase family.
    
  0.908
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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