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ptsH ptsH ptsI ptsI crr crr ptsG ptsG mtlA mtlA fruA fruA manX manX nagE nagE manZ manZ cmtB cmtB agaW agaW
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ptsHPTS system protein HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (85 aa)    
Predicted Functional Partners:
ptsI
PEP-protein phosphotransferase system enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
 0.999
crr
PTS system, glucose-specific IIA component; Residues 1 to 169 of 169 are 99.40 pct identical to residues 1 to 169 of 169 from Escherichia coli K-12 Strain MG1655: B2417.
 
 0.999
ptsG
PTS system, glucose-specific IIBC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport. Also functions as a chemoreceptor monitoring the environment for changes in sugar concentration.
 
 
 0.991
mtlA
PTS system, mannitol-specific enzyme IIABC components; Residues 1 to 637 of 637 are 99.37 pct identical to residues 1 to 637 of 637 from Escherichia coli K-12 Strain MG1655: B3599.
 
 
 0.989
fruA
PTS system, fructose-specific transport protein; Residues 1 to 563 of 563 are 99.46 pct identical to residues 1 to 563 of 563 from Escherichia coli K-12 Strain MG1655: B2167.
  
 
 0.988
manX
PTS enzyme IIAB, mannose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA.
  
 0.985
nagE
PTS system, N-acetylglucosamine-specific enzyme IIABC; Residues 1 to 648 of 648 are 99.53 pct identical to residues 1 to 648 of 648 from Escherichia coli K-12 Strain MG1655: B0679.
 
 0.969
manZ
PTS enzyme IID, mannose-specific; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA.
    
 0.969
cmtB
PTS system, mannitol-specific enzyme II component, cryptic; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
  
 
 0.937
agaW
Putative phosphotransferase system enzyme subunit; Residues 1 to 259 of 259 are 78.76 pct identical to residues 1 to 258 of 258 from GenPept 118 : gi|1732200|gb|AAC44680.1| (U65015) PTS permease for mannose subunit IIPMan [Vibrio furnissii].
    
 0.936
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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