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nanT nanT nanA nanA yhcJ yhcJ yhcI yhcI yhcH yhcH yhcK yhcK yjhA yjhA yjhT yjhT nagB nagB yjhS yjhS nagE nagE
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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nanTSialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (506 aa)    
Predicted Functional Partners:
nanA
N-acetylneuraminate lyase (aldolase); Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
 
  
 0.969
yhcJ
Putative enzyme; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).
 
  
 0.963
yhcI
Putative NAGC-like transcriptional regulator; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.
 
  
 0.934
yhcH
Orf, hypothetical protein; Residues 1 to 154 of 154 are 96.10 pct identical to residues 1 to 154 of 154 from Escherichia coli K-12 Strain MG1655: B3221.
 
  
 0.928
yhcK
Putative FADA-type transcriptional regulator; Transcriptional repressor that controls expression of the genes required for the catabolism of sialic acids.
 
   
 0.908
yjhA
Orf, hypothetical protein; Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria. NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity (By similarity).
   
  
 0.811
yjhT
Orf, hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses; Belongs to the NanM family.
  
  
 0.807
nagB
Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
      
 0.730
yjhS
Orf, hypothetical protein; Residues 1 to 326 of 326 are 97.54 pct identical to residues 1 to 326 of 326 from Escherichia coli K-12 Strain MG1655: B4309.
      
 0.720
nagE
PTS system, N-acetylglucosamine-specific enzyme IIABC; Residues 1 to 648 of 648 are 99.53 pct identical to residues 1 to 648 of 648 from Escherichia coli K-12 Strain MG1655: B0679.
      
 0.701
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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