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algD algD algA algA alg8 alg8 alg44 alg44 PP_1776 PP_1776 algX algX algK algK algG algG algE algE gmd gmd algL algL
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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gene co-occurrence
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textmining
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protein homology
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algDGDP-mannose 6-dehydrogenase; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics (By similarity). (438 aa)    
Predicted Functional Partners:
algA
Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics (By similarity).
 
 
 0.996
alg8
Glycosyltransferase alg8; Possibly a processive enzyme that polymerizes GDP-mannuronic acid.
 
 
 0.996
alg44
Alginate biosynthesis protein Alg44; Required for alginate biosynthesis.
  
 
 0.993
PP_1776
Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.972
algX
Alginate biosynthesis protein AlgX; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Probably has acetyltransferase activity in vivo (By similarity).
 
  
 0.950
algK
Alginate biosynthesis protein AlgK; May be involved in the polymerization of mannuronate to alginate.
  
  
 0.936
algG
poly(beta-D-mannuronate) C5 epimerase; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate. In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE.
  
  
 0.932
algE
Alginate production protein AlgE; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore.
  
  
 0.932
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
 
 
 0.929
algL
Alginate lyase; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space.
  
  
 0.926
Your Current Organism:
Pseudomonas putida KT2440
NCBI taxonomy Id: 160488
Other names: P. putida KT2440, Pseudomonas putida (strain KT2440), Pseudomonas putida str. KT2440
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