STRINGSTRING
hisD2 hisD2 hisB hisB hisI hisI hisC hisC hisG hisG hisF hisF hisH hisH hisA hisA hutH hutH hisD1 hisD1 cobC cobC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hisD2Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase; Identified by similarity to SP:P06987; match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
 
 0.999
hisI
phosphoribosyl-ATP pyrophosphatase/phosphoribosyl-AMP cyclohydrolase; Identified by similarity to SP:P06989; match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family.
  
 0.999
hisC
Histidinol-phosphate aminotransferase; Identified by similarity to SP:P10369; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 0.997
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
 0.988
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.984
hisH
Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.972
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to SP:P10371; match to protein family HMM PF00977; match to protein family HMM TIGR00007.
 
  
 0.972
hutH
Histidine ammonia-lyase; Identified by match to protein family HMM PF00221; match to protein family HMM TIGR01225.
    
 0.918
hisD1
Histidinol dehydrogenase; Identified by match to protein family HMM PF00815; match to protein family HMM TIGR00069.
  
  
 
0.917
cobC
cobC protein; Identified by similarity to SP:P21633.
 
  
 0.817
Your Current Organism:
Colwellia psychrerythraea
NCBI taxonomy Id: 167879
Other names: C. psychrerythraea 34H, Colwellia psychrerythraea 34H, Colwellia psychrerythraea str. 34H, Colwellia psychrerythraea strain 34H, Colwellia sp. 34H
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