STRINGSTRING
eno eno pgk pgk fba fba pykF pykF gpi gpi gpmA gpmA gapA gapA tpi tpi ppc ppc tktA tktA rplD rplD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (434 aa)    
Predicted Functional Partners:
pgk
Phosphoglycerate kinase.
 
 
 0.997
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 0.995
pykF
Pyruvate kinase I; fructose-stimulated.
 
 0.994
gpi
Glucose-6-phosphate isomerase.
  
 0.992
gpmA
Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
  
 0.986
gapA
Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
 
 
 0.983
tpi
Triose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
 
 0.979
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
  
 
 0.928
tktA
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
   
 0.926
rplD
50S Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
  
 
 0.900
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.