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ahpC ahpC ahpF ahpF SERP0488 SERP0488 trxB trxB perR perR katA katA SERP1047 SERP1047 SERP2384 SERP2384 dnaK dnaK sodA sodA ftnA ftnA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ahpCAlkyl hydroperoxide reductase, C subunit; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (189 aa)    
Predicted Functional Partners:
ahpF
Alkyl hydroperoxide reductase, F subunit; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity); Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
 
  
 0.999
SERP0488
Thioredoxin, putative.
  
 0.973
trxB
Thioredoxin-disulfide reductase; Identified by similarity to SP:P80880; match to protein family HMM PF00070; match to protein family HMM TIGR01292.
  
 
 0.812
perR
Transcriptional regulator, Fur family; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. May act as a hydrogen peroxide and organic hydroperoxide sensor (By similarity). Belongs to the Fur family.
  
  
 0.749
katA
Catalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.
  
 
 0.736
SERP1047
Pyridine nucleotide-disulfide oxidoreductase family protein; Identified by match to protein family HMM PF00070.
  
 
 0.718
SERP2384
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SA2469.
  
 
 0.718
dnaK
dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 
 0.689
sodA
Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.662
ftnA
Ferritin family protein; Iron-storage protein.
  
  
 0.651
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
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