Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SERP0163 | clpC | SERP0163 | SERP0165 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | 0.950 |
| SERP0163 | ctsR | SERP0163 | SERP0162 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.986 |
| SERP0163 | mcsB | SERP0163 | SERP0164 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | ATP:guanido phosphotransferase family protein; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. | 0.996 |
| SERP0163 | nupC | SERP0163 | SERP0161 | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | Nucleoside permease NupC; Identified by similarity to EGAD:30360; match to protein family HMM PF01773. | 0.818 |
| clpC | SERP0163 | SERP0165 | SERP0163 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | UvrB/UvrC domain protein; Identified by match to protein family HMM PF02151. | 0.950 |
| clpC | clpP | SERP0165 | SERP0436 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.981 |
| clpC | ctsR | SERP0165 | SERP0162 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.984 |
| clpC | dnaJ | SERP0165 | SERP1147 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.841 |
| clpC | dnaK | SERP0165 | SERP1148 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.947 |
| clpC | groES | SERP0165 | SERP1485 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.802 |
| clpC | grpE | SERP0165 | SERP1149 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.823 |
| clpC | mcsB | SERP0165 | SERP0164 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | ATP:guanido phosphotransferase family protein; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. | 0.986 |
| clpC | mecA-2 | SERP0165 | SERP0578 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Negative regulator of competence MecA, putative; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.991 |
| clpC | nupC | SERP0165 | SERP0161 | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | Nucleoside permease NupC; Identified by similarity to EGAD:30360; match to protein family HMM PF01773. | 0.810 |
| clpP | clpC | SERP0436 | SERP0165 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit ClpC; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. | 0.981 |
| clpP | ctsR | SERP0436 | SERP0162 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Transcriptional regulator CtsR; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. | 0.501 |
| clpP | dnaJ | SERP0436 | SERP1147 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.579 |
| clpP | dnaK | SERP0436 | SERP1148 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.768 |
| clpP | groES | SERP0436 | SERP1485 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperonin, 10 kDa; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.745 |
| clpP | grpE | SERP0436 | SERP1149 | ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.687 |
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