STRINGSTRING
ypfP ypfP ltaA ltaA ltaS ltaS geh-1 geh-1 SERP2336 SERP2336 SERP0018 SERP0018 geh-2 geh-2 dagK dagK ftsZ ftsZ divIB divIB tagF tagF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ypfPypfP protein; Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer two glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O- (beta-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1->6)-D-glucopyranosyl)-1,2-diacyl- sn-glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA). (391 aa)    
Predicted Functional Partners:
ltaA
Membrane protein, putative; Probable permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl-diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence (By similarity); Belongs to the major facilitator superfamily. LtaA family.
 
   
 0.987
ltaS
Sulfatase family protein; Catalyzes the polymerization of lipoteichoic acid (LTA) polyglycerol phosphate, a reaction that presumably uses phosphatidylglycerol (PG) as substrate. Is required for staphylococcal growth and cell division process (By similarity).
  
 
 0.981
geh-1
Lipase; Identified by similarity to GP:2981225; match to protein family HMM PF04650; match to protein family HMM TIGR01168; Belongs to the AB hydrolase superfamily. Lipase family.
  
  
  0.914
SERP2336
Lipase, putative; Identified by similarity to SP:Q02510; match to protein family HMM PF04650; match to protein family HMM TIGR01168.
  
  
  0.914
SERP0018
Lipase, putative; Identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168.
  
  
  0.913
geh-2
Lipase; Identified by similarity to GP:3789932; match to protein family HMM PF04650; match to protein family HMM TIGR01168.
  
  
  0.912
dagK
Conserved hypothetical protein TIGR00147; Catalyzes the phosphorylation of diacylglycerol (DAG) into phosphatidic acid. Is a key enzyme involved in the production of lipoteichoic acid by reintroducing DAG formed from the breakdown of membrane phospholipids into the phosphatidylglycerol biosynthetic pathway (By similarity); Belongs to the diacylglycerol/lipid kinase family.
    
  0.900
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 0.762
divIB
Cell division protein FtsQ, putative; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily.
  
  
 0.761
tagF
Teichoic acid biosynthesis protein F; Responsible for the polymerization of the main chain of the major teichoic acid by sequential transfer of glycerol phosphate units from CDP-glycerol to the disaccharide linkage unit. Synthesizes polymers of approximately 35 glycerol phosphate units in length.
     
 0.720
Your Current Organism:
Staphylococcus epidermidis
NCBI taxonomy Id: 176279
Other names: S. epidermidis RP62A, Staphylococcus epidermidis ATCC 35984, Staphylococcus epidermidis RP62A, Staphylococcus epidermidis str. RP62A, Staphylococcus epidermidis strain RP62A
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.