node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | SERP0070 | SERP2302 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | 0.729 |
guaA | hisF | SERP0070 | SERP2301 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.428 |
guaA | hisH | SERP0070 | SERP2303 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.447 |
guaA | hisIE | SERP0070 | SERP2300 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family. | 0.636 |
guaA | ilvC | SERP0070 | SERP1668 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.460 |
hisA | guaA | SERP2302 | SERP0070 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.729 |
hisA | hisB | SERP2302 | SERP2304 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | 0.998 |
hisA | hisC | SERP2302 | SERP0387 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.916 |
hisA | hisD | SERP2302 | SERP2305 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | SERP2302 | SERP2301 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SERP2302 | SERP2306 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.995 |
hisA | hisH | SERP2302 | SERP2303 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisIE | SERP2302 | SERP2300 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase; Identified by similarity to EGAD:8260; match to protein family HMM PF01502; match to protein family HMM PF01503; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | hisZ | SERP2302 | SERP2307 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Conserved hypothetical protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). | 0.961 |
hisA | ilvC | SERP2302 | SERP1668 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.779 |
hisB | hisA | SERP2304 | SERP2302 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by similarity to OMNI:NTL01LL1240; match to protein family HMM PF00977. | 0.998 |
hisB | hisC | SERP2304 | SERP0387 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM PF00222; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SERP2304 | SERP2305 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | SERP2304 | SERP2301 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SERP2304 | SERP2306 | Imidazoleglycerol-phosphate dehydratase; Identified by similarity to EGAD:107380; match to protein family HMM PF00475. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.996 |