node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atu0988 | clpA | Atu0988 | Atu1364 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.866 |
Atu0988 | clpB | Atu0988 | Atu4177 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | 0.866 |
Atu0988 | clpB-2 | Atu0988 | Atu4344 | Molecular chaperone, Hsp70 family. | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.866 |
Atu0988 | grpE | Atu0988 | Atu0329 | Molecular chaperone, Hsp70 family. | GRPE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.944 |
Atu0988 | hslU | Atu0988 | Atu0045 | Molecular chaperone, Hsp70 family. | Heat shock chaperone; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.593 |
Atu0988 | hslV | Atu0988 | Atu0044 | Molecular chaperone, Hsp70 family. | Heat shock protein hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.539 |
Atu0988 | hspL | Atu0988 | Atu3887 | Molecular chaperone, Hsp70 family. | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.547 |
clpA | Atu0988 | Atu1364 | Atu0988 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, Hsp70 family. | 0.866 |
clpA | dnaK | Atu1364 | Atu0122 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | DNAK Protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.908 |
clpA | grpE | Atu1364 | Atu0329 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GRPE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.742 |
clpA | hslU | Atu1364 | Atu0045 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock chaperone; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.536 |
clpA | hslV | Atu1364 | Atu0044 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Heat shock protein hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.443 |
clpA | hspL | Atu1364 | Atu3887 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.702 |
clpB | Atu0988 | Atu4177 | Atu0988 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Molecular chaperone, Hsp70 family. | 0.866 |
clpB | dnaK | Atu4177 | Atu0122 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | DNAK Protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.932 |
clpB | grpE | Atu4177 | Atu0329 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | GRPE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.874 |
clpB | hslU | Atu4177 | Atu0045 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Heat shock chaperone; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.538 |
clpB | hslV | Atu4177 | Atu0044 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Heat shock protein hslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.445 |
clpB | hspL | Atu4177 | Atu3887 | ATP-dependent Clp protease, ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the [...] | Small heat shock protein; Belongs to the small heat shock protein (HSP20) family. | 0.702 |
clpB-2 | Atu0988 | Atu4344 | Atu0988 | ATP-dependent Clp protease, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Molecular chaperone, Hsp70 family. | 0.866 |